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Which metabolic pathways are affected

In the STEP 1 trial extension, participants regained roughly two-thirds of their lost weight in the year after stopping semaglutide, with cardiometabolic improvements largely reverting toward baseline

Funding acquisition: D.C

The peptide has a relatively short half-life of approximately 20 minutes, meaning it clears the body quickly while stimulating growth hormone release that lasts much longer

It works by reducing appetite, and researchers are now studying similar drugs, including tirzepatide, which is pending FDA approval for obesity, and retatrutide, which must still undergo further clinical trials on obesity and diabetes