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Hormone therapy acquired resistance occurs after the suppression of ER function with selective estrogen receptor modulators (SERMs) such as tamoxifen 75 or by lowering serum estradiol (E2) levels or blocking peripheral conversion of adrenal precursors with aromatase inhibitors

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After culturing at 37C for 18 h, the total bacterial counts (CFU/mL) were recorded

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In so doing, it is hoped that a more systems-oriented, less reductionist approach to the functioning of an important enzyme might help encourage a similar approach to researching and understanding what effects CAM therapies are having at the biochemical level