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GPCR dynamics: structures in motion

In vivo studies show that muscle-specific triple knockout of FoxO1/3/4 abolishes the induction of 29 atrogenes-including E3 ligases, autophagy mediators, deubiquitinases (e.g., USP14), and proteasome subunits (e.g., Psmd11)-under catabolic stimuli, preserving muscle mass and strength (Sanchez et al., 2014)

When dietary, behavioral, and pharmacological approaches fail, surgery could represent a valid therapeutic option in selected cases and in the presence of severe and progressive obesity with serious comorbidities

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605 There is a potential association between abnormal fatty acid metabolism and the pathogenic activation of Th cells in autoimmune diseases