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Taken together these results shed light on P4HA1 function in PDAC stroma as a molecular player of stroma deposition in pancreatic cancer development upon metabolic syndrome, ultimately suggesting hydroxyproline levels as potential PDAC biomarkers

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Foundational insights into proteostasis were laid in the 1940s, when Rudolf Schoenheimer conceptually established the dynamic turnover of body proteins, demonstrating continuous synthesis and degradation (Fig

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