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Circulation 141 , 940942 (2020)

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And do they reduce harm in people already struggling with it?Among people with no prior addiction, GLP-1 drugs were associated with lower risk of addiction across substances: Opioids: 25% Cocaine: 20% Nicotine: 20% Alcohol: 18% Cannabis: 14% Consistent across every substance we tested.Among people already living with addiction: 50% fewer substance-related deaths 39% fewer drug overdoses 31% fewer ER visits 26% fewer hospitalizations 25% fewer suicide attempts Over 3 years: 12 fewer serious events and 2 fewer deaths per 1,000 peopleMost remarkable: these drugs work across various addictive substances, suggesting shared biology