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Stimulation of melanocytes by an MC1R agonist could theoretically promote progression of pre-existing melanocytic lesions to malignant melanoma

These medications have been studied extensively in clinical trials and have clear dosing escalation schedules, known side effect profiles, and consistent pharmacokinetics when delivered by injection

Novo Nordisk, the maker of these weight-loss drugs, does not include warnings about the increased risk of gastroparesis/stomach paralysis (frozen stomach) for people who consume the medications or receive GLP-1 RA treatments

Dehydration represents another important contributor, as reduced oral intake due to nausea or early satiety combined with gastrointestinal losses can lead to volume depletion

Yang Y, Degranpr P, Kharfi A, Akoum A