Why Mechanism Does Not Guarantee Clinical Results Mechanistic findings are useful for hypothesis-building, but clinical outcomes require human studies with defined populations, formulations, controls, durations, and endpoints
In other words, youre fighting a localized histamine storm at the injection site
Unfortunately, patients often meet the KCC and lactate criteria quite late in the course of the disease, so these criteria are not useful as early predictors or as standards for transfer to a facility that performs the hepatic transplant
We should look to expand our horizons, and if the experience is not always an unadulterated positive, who can say what others might like, what the companys ten year old is like, or where it moves in the future
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