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In an attempt to achieve this aim, different combination therapies have been proposed over the past few years that are based on treatments tackling the various mechanisms involved in the destruction of cells

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Along with truncating the C-terminal, this exposes exenatide to NEP 24.11 degradation.43 Besides, attaching the GLP-1 C-terminal to exenatide (3139) can prevent DPP-4 degradation.44 With C-terminal curtailing, the insulinotropic activity of exenatide gradually declines

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