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In most cases, these reactions are self-limited and improve with proper site rotation and injection technique

Sample size planning was guided by previous literature on the streptozotocin (STZ) model and anticipated effect sizes, with allowance for expected attrition during the experimental period

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Fundamentally, aging is driven by the cumulative effects of cellular senescence ( The strategies to address senescent cells and replenish exhausted stem cells during the aging process, as well as supplementing metabolic substances like NAD+, gene therapy, or epigenetic approaches to mitigate aging, are different because they aim to promote the repair of senescent cells rather than inducing their apoptosis ( The Forkhead box O (FOXO) proteins are an important subclass of the Forkhead family

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