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Route: Administered subcutaneously or orally (semaglutide)

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[13] An alternate study conducted by REWIND [17] had enrolled a lower-risk population consisting of 9901 patients, two-thirds had no prior cardiovascular events

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This is consistent with the outcomes of previous studies in people with type 2 diabetes, in which metformin, even after sustained exposure, did not affect insulin sensitivity, as assessed using hyperinsulinaemiceuglycaemic clamp techniques [39, 40]