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These results suggested that CXCL10IL18R1 activates the three downstream pathways independent of other CXCRs (Supplementary Fig

Rapid induction of intracellular GSH synthesis occurs in response to various oxidative stress parameters, which is a critical determinant of cellular tolerance to oxidative stress (12)

Consistency of findings from between-trial and within-trial comparisons, formal statistical testing verifying the absence of a subgroup effect and the similarity of baseline cardiovascular risk across different cardiovascular risk categories between individual CVOTs despite the use of seemingly different enrolment criteria suggest the benefits of the use of SGLT2i or GLP-1 RA in people with type 2 diabetes and established CVD and in those at high cardiovascular and/or kidney risk [142, 253]

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