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Because GH is known to stimulate lipolysis (fat breakdown) and improve body composition, the authors concluded that ipamorelin effectively activates the GH axis in humans, a key pathway associated with potential fat loss effects

RGFP966 treatment caused induction in the expression of macrophage migration inhibitory factor, which is associated with activation of glial cells (Jia et al., 2016)

Researchers reach for this combination when the goal is not just appetite control but metabolic efficiency during a hard fat-loss phase