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Bridging this translational gap will require rigorous clinical validation, improved delivery strategies, and careful regulatory frameworks to ensure safe and effective integration of peptide therapeutics into musculoskeletal medicine

Encouraging results have also been reported with mazdutide (LY3305677) in terms of BW, blood pressure (BP), glucose and lipid lowering 47 , and efinopegdutide (MK-6024) in terms of liver fat content in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) with or without T2D 48

As a result, marginal territories are perceived as "places of elsewhere" (Membretti et al., 2022), distant from the values and dynamics of cultural production