The literature search supports the conclusion that metformin is neuroprotective against DM-induced neuronal cell degeneration in both peripheral and central nervous systems, and this effect is likely mediated via modulation of oxidative stress, inflammation, and cell death pathways
doi: 10.3389/fmed.2021.689042 Received 31 March 2021 Accepted 15 June 2021 Published 09 August 2021 Volume 8 - 2021 Edited by Oscar Escribano, Complutense University of Madrid, Spain Reviewed by Adriaan Holleboom, Academic Medical Center, Netherlands
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