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Another placebo-controlled study 35 reported clinical improvement alongside circadian biomarker assessment, noting that seven participants had more than a 10-point decrease in DSM-III-R depression score after ALC treatment

Finally, in a recent systematic review [79] of nine studies investigating the co-supplementation of omega-3 fatty acids with vitamin E for oxidative stress parameters, no significant changes were seen in glutathione concentrations or select enzymes such as superoxide dismutase and catalase

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Omega-3s can inhibit platelet aggregation, thrombin, and clot formation, as well as improve vasodilation