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Antinociceptive and Analgesic Effects DSIP demonstrated a potent antinociceptive effect when administered intracerebroventricularly or intracisternally in rodent models establishing central analgesic activity independent of peripheral opioid mechanisms

Downstream effector kinases of CaMKK2 Four known downstream effectors of CaMKK2 are the Ca 2+ -calmodulin-dependent protein kinases-1 and -4 (CaMK1 and CaMK4), the AMP-activated protein kinase (AMPK), and Akt/protein kinase-B (PKB) [86,87,88,89,90,91,92,93]

In contrast, nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy promotes ferritin degradation and iron release

In conclusion, we have developed and extensively characterised the NAPstar family, which are bona fide biosensors of the NADP redox state

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