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Based on these observations it was concluded that folding of permuted dihydrofolate reductase variants was terminated at the stage of the molten globule formation, whereas their interaction with ligands promoted structural adjustments and formation of active protein molecules, indicating ligand-induced transition from the molten globule to the native state (Uversky et al., 1996)

| 06.12.26 | 10 min read

Disorders of these metabolites also increase the burden on the diabetic kidneys

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