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58 GLP-1RAs potentially may reduce the risk of AF onset and progression through direct and indirect effects on atrial remodelling, including a reduction in systemic inflammation, improvement of cardiomyocyte metabolism, autonomic nervous system modulation, regulation of intracellular Ca 2+ levels and prevention and possibly reversion of atrial fibrosis

[55] A randomized, double-blind, placebo-controlled study from 2006 assigned participants to one of four groups for the 12 week study period besides the placebo group, one got grapefruit juice, another fresh grapefruit, and finally, the fourth group took capsules continuing grapefruit extract