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In the obese trial cohort, 1 mg moved 24-hour heart rate by +0.7 bpm in the first week, essentially placebo. In a healthy lean Phase 1b group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population

Grouping: Sham group (physiological saline), OVX control group (physiological saline), AOD 9604 Capsule low-dose group (100 g/kg/day), AOD 9604 high-dose group (500 g/kg/day), positive drug group (teriparatide, 20 g/kg/day)

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Confirmation most often relies on nonspecific precipitation, which can give misleading results