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TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

2017 study reported improvements in aged mice that were sustained through the observation period, suggesting that senescent cell clearance produces durable benefits once senescent cells are eliminated, their pro-inflammatory SASP burden is removed, allowing tissue recovery that persists beyond the treatment window

Neurological manifestations are particularly significant and may include paraesthesia (pins and needles) in the hands and feet, numbness, muscle weakness, and problems with balance and coordination

H., Shug, A

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