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However, if you have sensitive skin, it is suggested to use a lower concentration (510%) with a patch test
The Pro-Gly-Pro (PGP) addition is a stabilising motif that protects against enzymatic degradation and increases half-life
Documentation Burden: To be legal, the prescriber must document why the combination product is medically necessary for that specific patient (e.g., severe non-compliance with multiple distinct administrations)
Still under investigation , not yet FDA-approved as of 2025
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