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Research has examined its effects on fibroblast migration, endothelial tube formation, extracellular matrix remodeling, and the nitric oxide system, making it a widely used tool in regenerative and vascular biology research

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3 RGN-259 Phase 3 Trial in Neurotrophic Keratopathy Sosne et al., International Journal of Molecular Sciences (2022) This Phase 3 randomized, placebo-controlled, double-masked clinical trial evaluated topical 0.1% RGN-259 (full-length recombinant T4 ophthalmic solution) in patients with neurotrophic keratopathy

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