D.Van RaalteD
the thyroid medication needs adjustment, not the GLP-1 agonist
The combined SUSTAIN, FLOW, and PIONEER trial programs have enrolled more than 15,000 patients and consistently demonstrated benefits beyond glycemic control, including reduced cardiovascular events, slower progression of kidney disease, and modest weight loss
While B12 plays a role in energy metabolism and red blood cell production, it's important to note that supplementation will only improve energy levels in people with an existing deficiency
Tirzepatide-based evidence from the SURPASS (Researching Tirzepatide in Patients with Type 2 Diabetes for Glycemic Control and Weight Management) trials (SURPASS-1 NCT03954834 and SURPASS-5 NCT04039503) demonstrated dose-dependent, significant weight loss over 40 weeks compared with placebo, along with reductions in BMI and waist circumference [62, 63]