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Many people regain weight when they stop taking them, which is why patients should think carefully about whether they are ready for long-term treatment, at least until we have better evidence on how to maintain weight loss after stopping medication or treatments that more durably change the course of obesity

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DIFFERENTIAL DIAGNOSIS OF THE PSEUDO-HUTCHINSON SIGN The Hutchinson nail sign, first described in 1886, is a periungual band of brown-black pigmentation extending from the nail matrix onto the surrounding tissue, usually due to progression of subungual melanoma

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