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cerebrovascular damage, characterized by microinfarcts, amyloid angiopathy, or endothelial dysfunction disrupting the bloodbrain barrier (BBB) integrity
Past studies have demonstrated that taurocholate acid (TCA) can promote the colonization and transmission of C
PMID: 27288086 Abstract Author(s): Toshihiro Kurahashi, Jaeyong Lee, Atsunori Nabeshima, Takujiro Homma, Eun Sil Kang, Yuka Saito, Sohsuke Yamada, Toshiyuki Nakayama, Ken-Ichi Yamada, Satoshi Miyata, Junichi Fujii Abstract: Aldehyde reductase (AKR1A) plays a role in the biosynthesis of ascorbic acid (AsA), and AKR1A-deficient mice produce about 10-15% of the AsA that is produced by wild-type mice
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The apo-form of the GCGR receptor may exist in a closed state as shown by dynamic simulation where the -helix of the ECD is parallel to the plane of the membrane and a conformational change is required to adopt the open glucagon-bound state of GCGR 22
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