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We confirmed both in vitro and in vivo that specific combination of ligands of different transporters, especially alanine and glutathione, is more efficient than single ligands to facilitate the penetration of nanocarrierss across the BBB [24, 32, 33, 42]

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An empty stomach at the time of injection (no food for two hours prior, carbohydrates especially) measurably increases the magnitude of the GH response