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Based on trial eligibility, retatrutide is being investigated in adults who broadly meet the following criteria: BMI of 30 kg/m or above (classified as obese), or BMI of 27 kg/m or above with at least one weight-related comorbidity, such as type 2 diabetes, hypertension, or dyslipidaemia Adults who have not achieved adequate weight loss through lifestyle interventions alone Retatrutide trials to date have enrolled adults only