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Patients who experience side effects should report them to their healthcare professional or directly to the MHRA through the Yellow Card scheme (yellowcard.mhra.gov.uk)

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The combination of GLS inhibitors, such as CB-839, with ASNase, works synergistically by not only inhibiting asparagine synthesis but also enhancing its degradation

Although considerable progress has been made in understanding the interplay between mitochondrial dysfunction and FAO disorders in HF, several limitations remain