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Reported side effects may include: Injection-site redness Mild swelling Temporary discomfort Bruising Headache Fatigue Nausea Skin irritation Allergic reactions In addition to ingredient-related effects, there are also important considerations regarding manufacturing quality

If you're reconstituting something sensitive to preservatives, or you only need a single-use preparation, sterile water is usually preferred

A 6mg/mL concentration (30mg vial in 5.0mL) would require a 2mL injection for a 12mg dose, which is within the standard range for subcutaneous administration

Clin Sci (Lond) 132:399418 Qiang MQ, Reiter RJ, Chen Y (2020) Role of melatonin in controlling angiogenesis under physiological and pathological conditions