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This is due to the fact that M1 macrophages, which are pro-inflammatory, possess higher concentrations of inducer nitric oxide synthase (iNOS), leading to a greater production of nitric oxide free radicals and stronger protection against lipid peroxidation, when compared to M2 macrophages, which are anti-inflammatory and have lower iNOS concentrations (83)

Identify success criteria (50% pain reduction, specific functional milestone) guiding protocol duration and modification decisions

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Suzhou-based Innovent Biologics saw its obesity drug, Mazdutide, approved by Chinese regulators last yearand according to a 2025 report released by LEK Consulting, China has more than 60 obesity drug candidates under development that are set to compete with those produced in the United States