Ccrk depletion causes severe progressive retinal degeneration very similar to that observed in Mak Ick DKO mice To elucidate regulatory mechanisms of Mak and Ick activity in retinal photoreceptor cells, we focused on phosphorylation of the Mak and Ick proteins, because high-throughput phosphoproteomic analyses have shown that Mak and Ick are extensively phosphorylated at residue 157 (PhosphoSitePlus) (60), which is located in the kinase domain showing a high similarity of amino acid sequence and predicted structure between Mak and Ick (Fig 5A)
While typically not dangerous, cold sensitivity can impact quality of life and may require adaptation strategies
A monthly injection could reduce the number of doses from 52 per year to just 12
Economopoulou P, Kotsantis I, and Papaxoinis G, et al (2020) Association of autoimmunity with survival in patients with recurrent/metastatic head and neck squamous cell carcinoma treated with nivolumab Oral Oncol 111 105013 PMID: 32977184 69
These options undergo rigorous quality control and may be covered by some insurance plans or fully eligible for HSA withdrawal, depending on your plan's formulary and your provider's medical documentation
