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These effects are rare at FDA-approved dosing but become significantly more likely when doses are doubled or tripled without medical supervision

A medically supervised weight loss program may help support improvements in: Healthy body weight and body composition Appetite control and reduced cravings Blood sugar regulation Insulin resistance Blood pressure Cholesterol levels Energy and daily activity Overall wellness and quality of life For many patients, losing weight can also reduce the impact of obesity-related conditions such as type 2 diabetes, high blood pressure, heart disease, metabolic syndrome, and certain sleep-related concerns

The most significant changes were observed at the highest dosages of tirzepatide, i.e., 10 and 15 mg [89, 90]

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discontinue if weight loss is less than 5% of initial body weight For liraglutide (Saxenda): Evaluate after 12 weeks at the full dose (3.0 mg daily)