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Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese enhanced magnetic resonance imaging

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Clinically, GLP-1-based therapies offer the additional advantage of established cardiovascular protection and renal benefits, making them particularly attractive for the large proportion of MASLD patients with comorbid cardiovascular disease or type 2 diabetes

Meanwhile, traditional herbal medicines, due to their multi-component synergistic mechanisms of action (such as salidroside regulating the HPA axis and psilocybin/psilocin regulating 5-HT 2A ), are increasingly gaining attention in the field of depression treatment, offering new directions for developing low-side-effect, multi-pathway intervention strategies

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia