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However, the clinical translation of conventional animal-derived EVs faces significant challenges, including inherent heterogeneity, difficulties in scalable production, and ethical concerns

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J Clin Invest 119(7):18581870 Seki E, de Minicis S, Inokuchi S, Taura K, Miyai K, van Rooijen N et al (2009) CCR2 promotes hepatic fibrosis in mice