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Contraindications include personal or family history of medullary thyroid cancer, severe pancreatitis, or certain gastrointestinal conditions

Nature 458 (7239), 762765

Risperidone When administered concomitantly with topiramate at escalating doses of 100, 250, and 400 mg/day, there was a reduction in risperidone systemic exposure (16% and 33% for steady-state AUC at the 250 and 400 mg/day doses of topiramate)