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Neurotoxicol 29:190201, PMID: 1803-1821 Looney JM, Childs HM (1934) The lactic acid and glutathione content of the blood of schizophrenic patients

The structure of enzymes can be changed by active plasma species by cleavage of chemical bonds and side-chain modifications

certain chemotherapy agents may interact

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Taking into account the instability of Fer-1 and its implications for further clinical application, as well as the crucial anti-ferroptosis role of GPX4, we identified a small molecule urolithin A (UA) through virtual screening and molecular docking targeting GPX4, which possesses stable physicochemical properties, minimal toxicity, antioxidant and rejuvenating properties, significantly improving osteogenic function [18, 19]