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Meanwhile, Gantz I, Fong TM

Furthermore, the change in the HbA1c value from baseline did not affect the result, suggesting that once-weekly exenatide reduced albuminuria independent of the glucose-lowering effect (Van Der Aart-Van Der Beek et al., 2020)

Continuous receptor activation isn't inherently superior to pulsed stimulation for compounds like Dihexa where the therapeutic effect derives from triggered structural changes rather than ongoing receptor occupancy

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Although CD45 staining was also performed on pancreatic sections, intact islets were largely absent in vehicle-treated mice, precluding meaningful quantification