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This simple step can dramatically prolong its stability

We identify the conformationally flexible TM1 as a key helix with dual function, as residues on this helix contribute to both Na + -binding and extracellular gating formation

In various in-vivo and in-vitro studies, exogenous administration of IGF-1 mediated has been shown to increase glucose utilization, release acetylcholine from neurons, activate N-methyl-D-aspartate receptor (NMDA), protect the cerebromicrovascular environment, and maintenance of synaptic structure and function [36, 41,42,43,44,45]

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Focus on nutrient density since volume remains limited