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Moreover, HCG supplement did not synergize with Anti-LOX + VED to accelerate tunica albuginea remodeling nor facilitate penile growth, although they had no impact on erectile function

IGF-DES functions through direct activation of the IGF-1 receptor (IGF-1R) tyrosine kinase, bypassing the IGFBP regulatory system that normally sequesters the majority of circulating native IGF-1

Together, these findings position NRF2 as the central mediator of melatonin-induced metabolic reprogramming and functional suppression in ILC2s and identify NRF2 as a therapeutically actionable target

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