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Although deficiency is associated with more advanced liver disease and portal hypertension, supplementation is generally not recommended, as the risks often outweigh the benefits

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In aged mice and human-derived immune cells from older individuals, Epitalon treatment was shown to increase CD4+ T cell populations within the bone marrow, helping to restore a more youthful and balanced immune profile [1]

Liver-specific knockout of ER in female rodents leads to increased lipid droplet deposition in the liver, increased hepatic inflammatory gene expression, and increased liver collagen deposition (24)

Science 340, 991994