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Diabetic rats treated for 42 d with a daily dose of 300 mg/kg of porcine skin gelatin showed their plasma glucose AUC reduced from 30 000 to 28 000 mg min/dl (1665 to 1554 mmol min/l), insulin levels increased 2-fold, active GLP-1 levels reduced from 15 to 135 pm and DPP4 activity reduced by half (Reference Huang, Hung and Jao48)

The researchers also conducted RNA-sequencing, which apparently pointed to reduced activity of pathways involved in ECMreceptor interaction and focal adhesion, alongside lower levels of key ECM proteins such as fibronectin, tenascin C, laminin, thrombospondin-2, and Hmmr

These benefits are critical for underserved populationswho are statistically more likely to face obesity, diabetes complications, and cardiovascular disease

Compound 102 also suppressed ferroptosis induced by GPX4 inhibitor RSL3 ( Supplementary Figure S14 )

Many people notice fewer extreme highs and lows in their glucose readings