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Additional Safety Information: Not recommended for individuals who are pregnant, breastfeeding, or planning to become pregnant or breastfeed

The secondary outcomes were the change of mean arterial blood pressure (delta MAP, %), the kinetics of arterial blood pressure, gap CO 2 , gap CO 2 /oxygen arteriovenous difference ratio, oxygen delivery (DO 2 ), oxygen consumption (VO 2 ), arterial lactate, hematocrit, sodium, and chloremia over a period of 60 min

The loading phase builds tissue concentration over 4 to 6 weeks, after which maintenance dosing preserves benefits with reduced frequency

This means that it is not possible to overdose on vitamin B12, and as far as we know there is no upper limit on the amount of B12 that can be taken safely by an otherwise healthy person

And I present my lady patient Mrs