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Many patients and their healthcare providers would prefer to avoid injections if possible due to the challenges associated with giving/receiving an injection, the complex storage conditions requiring freezing/refrigeration, and the short expiration dating per USP guidelines

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Evidence also suggests antidepressant effects of GLP-1RAs

While these agents offer substantial reproductive and metabolic benefits, their pharmacological effects, particularly delayed gastric emptying, raise the risk of regurgitation and aspiration during sedation

Microbially-derived SCFAs, such as butyrate, remodel the intestinal microenvironment by modulating TLR2/MyD88/NF-B signaling pathways, thereby enhancing the host's antioxidant defense mechanisms [30]