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Oxidative stress can lead to the oxidation of low - density lipoprotein (LDL) cholesterol, a major factor in the development of atherosclerosis

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78 In a patient with otherwise unexplained new onset polyarthritis, an urgent referral to a rheumatologist is thus mandatory to confirm an RA diagnosis and early initiation of a DMARDs-based treatment plan aiming for disease remission with prevention of deformity