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In order to test the induction of oxidative stress by FA more thoroughly, we incorporated the genetically-encoded cytosolic sensor roGFP

Westhovens R, Taylor PC, Alten R, Pavlova D, Enrquez-Sosa F, Mazur M, Greenwald M, Van Der Aa A, Vanhoutte F, Tasset C, Harrison P (2017) Filgotinib (GLPG0634/GS-6034), an oral JAK1 selective inhibitor, is effective in combination with methotrexate (MTX) in patients with active rheumatoid arthritis and insufficient response to MTX: results from a randomised, dose-finding study (DARWIN 1)

The antioxidant properties extend beyond simple free radical neutralization, encompassing support for cellular energy production, DNA repair mechanisms, and immune system function

Various studies have shown that GLP-1-based therapies can reduce macrophage infiltration and inflammatory molecules in models of diabetic nephropathy