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Pillar 4: GLP-1 receptor agonists and dual agonists GLP-1-based therapies (such as semaglutide and tirzepatide) are a legitimate pillar for insulin resistance management when obesity and/or appetite dysregulation are part of the picture
Due to limited data and relatively few clinical trials, many of these interventions need further investigation before they can be considered effective agents for routine clinical use
Environmental Science & Technology, 43(16): 62566261 Kravchenko I, Rayko M, Tikhonova E, Konopkin A, Abakumov E, Lapidus A (2022)
It becomes more functional
However, reassuringly, in the obesity phase 2 trial, self-reported physical function improved with all doses of retatrutide [45]
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