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Unfortunately, it can be converted into quinones and semiquinones, which in turn can covalently bond with DNA [2]

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During the development of osteoarthritis, the synovium undergoes interstitial vascularization, fibrosis and hyperplasia (167), and macrophages and fibroblasts in the synovium can release proinflammatory cytokines, etc., which cause synovitis and cartilage degeneration

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Here, we focused specifically on protein orthologs where the CSD is present, absent and also found as a single Cys

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