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Current therapies, including topical corticosteroids (TCS), topical calcineurin inhibitors (TCIs), and systemic agents, are effective for acute flare-ups but are limited by their narrow mechanisms of action and inability to provide sustained relief across all CHE subtypes [5, 71, 72]

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The GLP-1 system works through continuous receptor signaling, not dose accumulation, so a single extra injection won't 'catch you up' on weight loss from the missed week

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