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An animal study has shown that the combined use of 1-AR and -AR antagonists can slow the progression of liver fibrosis, particularly by reducing the activity of TGF- to decrease collagen accumulation, lowering portal vein pressure, improving liver hemodynamics, and alleviating complications associated with cirrhosis 71

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After 5 min only minor changes compared to untreated samples could be observed, showing the loss of H 2 O molecules