The most common side effects of oral silymarin ingestion include:2 Abdominal pain/fullness Bloating Bowel changes Diarrhea Dyspepsia (indigestion) Flatulence Headache Nausea Pruritus (itching) Of note, there's at least one case report of more severe instances of the above, along with sweating, colicky pain, weakness, and collapse, in a 57-year-old woman after taking a milk thistle capsule
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All this information that is being generated on the molecular and pharmacodynamic mechanisms leads us to see the need to create multidisciplinary investigative groups for the development of hepatoprotectors or hepatic antioxidants
Interestingly, antioxidants including vitamin E and N -acetylcysteine (NAC) attenuated the suppression of ethanol on hepcidin expression, the promoter activity of hepcidin, and the DNA binding activity of C/EBP, suggesting that oxidative stress contributed to the decline of hepcidin expression after ethanol exposure [78]